Education

Sep. 1995 - Feb. 1999

Dr. rer. nat. (Ph.D.)
Heinrich-Heine-University Düsseldorf, Germany
Molecular and Cell Biology

Oct. 1989 - Aug. 1995

Dipl.-Biol. (equivalent to Masters of Science)
Heinrich-Heine-University Düsseldorf, Germany
Microbiology, Physical Biology, Informatics

Research

Jul. 1999 - Jul. 2001

Postdoctoral Associate, Principal Investigator: Prof. Chris A. Kaiser
Department of Biology
Massachusetts Institute of Technology (MIT)
Cambridge, USA
Ubiquitin-regulated sorting in the late secretory pathway

Feb. 1999 -Jun. 1999

Postdoctoral Fellow, Principal Investigator: Prof. Jürgen Dohmen
Central Laboratory for Biotechnology, Institute for Microbiology
Heinrich-Heine-University Düsseldorf, Germany
Suppression of toxic effects caused by heterologous gene expression in S. cerevisiae

Sep. 1995 -Feb. 1999

Graduate Student, Principal Investigator: Prof. Ralf Kölling
Institute for Microbiology, Heinrich-Heine-University Düsseldorf, Germany
"Transport and Turnover of the ABC-Transporter Ste6p in Saccharomyces cerevisiae" (1998)

Oct. 1989 - Aug. 1995

Diploma Thesis (equivalent to Masters of Science), Principal Investigator: Prof. C. P. Hollenberg
Institute for Microbiology, Heinrich-Heine-University Düsseldorf, Germany
"Characterization of a protein-destabilizing motif" (1995)

Professional

Since Oct. 2009

Head of Product Management
Biomax Informatics AG,
Martinsried, Germany

Jan. 2005 - Sept. 2009

Product Manager Knowledge Management Solutions
Biomax Informatics AG,
Martinsried, Germany

Aug. 2001 - Dec. 2004

Project Manager Bioinformatics Projects,
Software-Development & Consulting
Biomax Informatics AG, Department of Scientific Bioinformatics
Martinsried, Germany
Proteomics, Systems Biology, Knowledge Management

Publications

2009

Maier D, Kalus W, Wolff M, Kalko SG, Roca J, Marin de Mas I, Turan N, Cascante M, Falciani F, Hernandez M, Villà-Freixa J, Losko S (2011) "Knowledge management for systems biology a general and visually driven framework applied to translational medicine" BMC Syst Biol. 2011 Mar 5;5:38, DOI: 10.1186/1752-0509-5-38

2009

Losko, S. and Heumann, K. (2009) "Semantic Data Integration and Knowledge Management to Represent Biological Network Associations", Methods Mol. Biol., Volume 563, 241-258, DOI: 10.1007/978-1-60761-175-2_13

2008

Hipp, S., Walch, A., Schuster, T., Losko, S., Laux, H., Bolton, T., Höfler, H. and Becker, K.-F., "Activation of epidermal growth factor receptor results in Snail protein but not mRNA over-expression in endometrial cancer", Journal of Cellular and Molecular Medicine, DOI: 10.1111/j.1582-4934.2008.00526.x

2006

Losko, S., Wenger, K., Kalus, W., Ramge, A., Wiehler, J. and Heumann, K. (2006), "Knowledge Networks of Biological and Medical Data: An Exhaustive and Flexible Solution to Model Life Science Domains", Lecture Notes in Computer Science, Volume 4075, Jan 2006, Pages 232 - 239, DOI: 10.1007/11799511

2002

Kaiser, C.A., Chen, E.J. and Losko, S. (2002) "Subcellular fractionation of secretory organelles", Methods Enzymol., 351, 325-338

2001

Helliwell, S.B., Losko, S. and Kaiser, C.A. (2001) "Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease", J. Cell Biol., 153(4), 649-662.

2001

Losko, S., Kopp, F., Kranz, A. and Kölling, R. (2001) "Uptake of the ABC-transporter Ste6 into the yeast vacuole is blocked in the doa4 mutant", Mol. Biol. Cell, 12, 1047-1059

1997

Kölling, R. and Losko, S. (1997) "The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein", Embo J., 16, 2251-2261, DOI: 10.1093/emboj/16.9.2251